We recently discussed the key features of our Visium Spatial Gene Expression and Xenium In Situ spatial transcriptomics...
Chromium Single Cell Immune profiling allows simultaneous analysis of T-cell receptor (TCR) sequences and gene expression profiles from the same individual cells, enabling researchers to measure clonal expansion and identify often overlooked immune cells in the tumor microenvironment.
10x Genomics has made a scientific breakthrough to resolve limitations of former methods when they introduced BEAM (Barcode Enabled Antigen Mapping).
The Innovator Blog Series celebrates research conducted by 10x Genomics customers who have demonstrated scientific ingen...
Looking back on 2023, we’re amazed and humbled to see the profound impact of Visium Spatial technology across a range of pioneering research endeavours. From uncovering novel T-cell states in cancer to deciphering genes crucial for palate development, each publication exemplifies Visium’s capacity to unveil spatially resolved, whole-transcriptome insights that redefine our understanding of complex biological processes. These studies not only highlight the power of unbiased spatial analysis but also underscore Visium’s role in advancing biomedical research by enabling new discoveries and therapeutic possibilities.
Researchers from the University of Tokyo, University of Ryukyus, and Daiichi Sankyo Co. used single-cell technologies, including Chromium Single Cell ATAC and Gene Expression assays, to uncover the mechanisms of action and resistance of valemetostat, a dual inhibitor targeting EZH1 and EZH2, in treating adult T-cell leukemia/lymphoma (ATL). They found that valemetostat reduces H3K27me3 levels, leading to chromatin relaxation and reactivation of tumor suppressor genes, which improves patient outcomes. Additionally, the treatment increases expression at previously repressed gene loci, countering the epigenetic repression observed in cancer cells. By exploiting Chromium Single Cell ATAC, these findings open a new realm of therapy development, offering promising directions for more effective and durable cancer treatments.
Cancer is a multifaceted disease driven by the complex interplay of diverse immune cells. To elucidate the heterogeneity of tumor microenvironments and assess the efficacy of innovative therapeutics, leveraging Chromium Single Cell Multiome ATAC + Gene Expression for comprehensive epigenetic profiling is essential. This advanced technique is pivotal in deciphering the mechanisms of gene activation and silencing that propel cancer progression.
Hematopoietic and pluripotent stem cells (HPSCs) mobilization is critical for effective autologous stem cell transplants...
Recent advancements have utilized the Chromium Single Cell Immune Profiling assay to develop an in-depth tumor microenvironment atlas, focusing on primary tumors, metastases, and particularly ascites – the fluid accumulation common in advanced cases. This study identified immune cells in ascites that could potentially enhance the immune response against primary and metastatic tumors.
