Spatial transcriptomics the next evolution of cancer drug discovery

Spatial transcriptomics is transforming cancer research by enabling detailed analysis of tumor complexity while preserving natural cell interactions. This innovative technique allows researchers to visualize gene expression patterns within the tumor microenvironment, uncovering interactions between different cell types and surrounding structures such as blood vessels and immune cells. By integrating spatial transcriptomics with advanced computational tools, scientists can identify biomarkers, map signaling pathways, and understand how these factors influence treatment response and resistance. This approach holds great promise for advancing personalized medicine in oncology, facilitating the development of targeted therapies tailored to individual patients based on their unique tumor biology.
Improving cancer diagnostics with exosomal ct-DNA

Improving cancer diagnostics with exosomal ct-DNA

Alex Rolland and his team at Cancer Treatment Options and Management Inc. focus on advancing oncology research to enhance cancer diagnostics and treatment effectiveness. Their collaboration with Norgen Biotek has yielded significant advancements in liquid biopsy technology, particularly in extracting circulating tumor DNA (ct-DNA) and exosomal RNA from patient blood samples. By utilizing Norgen's innovative extraction kits, they achieved high yields of cancer-specific ct-DNA fragments, crucial for monitoring treatment responses and disease progression. Their approach includes custom probes to monitor treatment responses and detect mutations, crucial for guiding personalized therapies and improving patient outcomes worldwide.
Single Cell Gene Expression

Multiomic single cell profiling reveals T-cell chromatin state primes cancer immunotherapy response

Cancer is a multifaceted disease driven by the complex interplay of diverse immune cells. To elucidate the heterogeneity of tumor microenvironments and assess the efficacy of innovative therapeutics, leveraging Chromium Single Cell Multiome ATAC + Gene Expression for comprehensive epigenetic profiling is essential. This advanced technique is pivotal in deciphering the mechanisms of gene activation and silencing that propel cancer progression.
Utilizing Single Cell RNA Sequencing to Target Ovarian Cancer

Utilizing Single Cell RNA Sequencing to Target Ovarian Cancer

Recent advancements have utilized the Chromium Single Cell Immune Profiling assay to develop an in-depth tumor microenvironment atlas, focusing on primary tumors, metastases, and particularly ascites – the fluid accumulation common in advanced cases. This study identified immune cells in ascites that could potentially enhance the immune response against primary and metastatic tumors.